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Signal Transduction and Human Disease - Finkel and Gutkind


Introduction xv
1 Atherosclerosis: Signal Transduction by Oxygen and Nitrogen
Radicals 1
Jonathan M. Hill, Ilsa I. Rovira, and Toren Finkel
2 NF-kB:A Key Signaling Pathway in Asthma 23
Stewart J. Levine
3 Molecular Mechanisms of Cancer 71
Akrit Sodhi, Silvia Montaner, and J. Silvio Gutkind
4 Apoptotic Pathways in Cancer Progression and Treatment 143
Joya Chandra and Scott H. Kaufmann
5 Molecular and Cellular Aspects of Insulin Resistance: Implications
for Diabetes 171
Derek Le Roith, Michael J. Quon, and Yehiel Zick
6 Dysfunction of G Protein-Regulated Pathways and
Endocrine Diseases 201
William F. Simonds
7 Bacterial Regulation of the Cytoskeleton 233
Jeremy W. Peck, Dora C. Stylianou, and Peter D. Burbelo
8 Bacterial Toxins and Diarrhea 259
Walter A. Patton, Joel Moss, and Martha Vaughan
9 Molecular Basis of Severe Combined Immunodeficiency: Lessons
from Cytokine Signaling Pathways 279
Roberta Visconti, Fabio Candotti, and John J. O’Shea

10 Mast Cell-Related Diseases: Genetics, Signaling Pathways,
and Novel Therapies 307
Michael A. Beaven and Thomas R. Hundley
11 Rheumatology and Signal Transduction 357
Keith M. Hull and Daniel L. Kastner
12 Molecular Mechanisms of Neurodegenerative Disorders 377
Benjamin Wolozin
13 Neurotrophic Signaling in Mood Disorders 411
Jing Du,Todd D. Gould, and Husseini K. Manji
14 Inhibiting Signaling Pathways Through Rational Drug Design 447
James N.Topper and Neill A. Giese

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